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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Michael J. Kruhlak

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Open access Aug 2026

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer

This study provides the first mechanistic characterization of KIF18A dependency in SCLC, identifying SAC competency as the primary determinant of response, and establishes a biologically informed framework for patient stratification and rational combination strategies.

Chiori Tabe, Rajesh Kumar, Yue Huang et al. · 0 citations
Open access Jul 2026

Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner

It is shown that disruption of chromatin organization by degron-mediated CTCF and/or WAPL depletion promotes totipotent-like conversion through the DPPA2/DUX axis, accompanied by changes in chromatin accessibility and nucleolar integrity.

Grace Carey, Maria Vega-Sendino, Desiree Tillo et al. · 2 citations

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