AQP4 Extended Region Binds to α-Syntrophin with a Novel Binding Motif.
Aquaporin-4 (AQP4) is an integral membrane protein channel specific for water molecules. It is highly polarized in the endfeet of astrocytes in the central nervous system where it allows water-ion homeostasis. AQP4 has two N-terminal isoforms: M1 (long) and M23 (short). Both isoforms retain their function but differ in...