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Author

Michael J. Strong

2 papers indexed here

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Review Open access Sep 2026

Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis-frontotemporal spectrum disorders.

Determining the optimal timing of disease-modifying therapies for neurodegenerative disorders will necessitate identification of when the underlying pathobiological process becomes active, well in advance of the point at which clinical manifestions appear. Phenoconversion, the emergence of clinically manifest syndomes,...

Michael J. Strong, Neil S. Donison, A. Al-Chalabi et al. · 0 citations
Open access Sep 2026

ARPP21 defines a TDP-43-independent aggregation pathway in amyotrophic lateral sclerosis

Currently, pathological inclusions of ubiquitinated TDP-43 are considered central to the pathogenesis of amyotrophic lateral sclerosis (ALS). However, this view has yielded sparse attention to covert alternative pathways of aggregation in the disease. Here, we identified a pathological axis independent of TDP-43 led by...

D. Campos-Melo, A. Dilliott, S. Farhan et al. · 0 citations

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