Insulin Dose-Adjusted Hemoglobin A1c Has Suboptimal Performance for Identifying C-Peptide-Defined Partial Remission: The SEARCH for Diabetes in Youth Study.
OBJECTIVE Insulin dose-adjusted hemoglobin A1c (IDAA1c = HbA1c [%] + [4 × total daily dose in units/kg/day]) ≤9 is widely used to define partial remission in pediatric type 1 diabetes and as an eligibility criterion or outcome in disease-modifying therapy trials. However, it has not been validated in U.S. youth. Becaus...