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Author

Michael Landowski

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Open access Oct 2026

The A53T Parkinson’s Disease Mouse Model Shows Abnormal Outer Retinal OCT Metabolic Biomarker Patterns

Purpose The purpose of this study was to test for abnormal optical coherence tomography (OCT) metabolic biomarker patterns in the A53T Parkinson's disease model, which accumulates α-synuclein in photoreceptor inner segments before overt motor symptoms. Methods Four-to-6-month-old transgenic A53T homozygous mice and B6C...

Ehimenmen S. Ataman, C. T. O. Nguyen, D. I. Finkelstein et al. · 0 citations
Open access Jul 2026

TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism

These findings identify TMEM135 as a central regulator of hepatic lipid metabolism and uncover a coordinated mechanism linking lipid availability, lipogenesis, and post-translational metabolic regulation.

Ryo Hagimori, Michael Landowski, Siyu Song et al. · 0 citations

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