Author

Michael P. Hier

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Open access Sep 2026

Prognostic Impact of Lymphovascular Invasion on Distant Metastasis in HPV-Negative Head and Neck Cancer.

BACKGROUND Lymphovascular invasion (LVI) is a recognized poor prognostic factor in head and neck squamous cell carcinoma (HNSCC), particularly for regional recurrence and overall survival. However, its role in predicting distant metastasis, especially in HPV-negative HNSCC, remains unclear. OBJECTIVE To evaluate the...

M. Khoury, Alex Mlynarek, Keith Richardson et al. · Head and Neck · 0 citations

Open access Oct 2026

Pretreatment Cachexia Index Is Associated With Severe Treatment Toxicity and Overall Survival in HPV-Negative Head and Neck Squamous Cell Carcinoma.

INTRODUCTION Cancer cachexia is characterized by skeletal muscle loss, poor nutrition, and systemic inflammation and is common in head and neck cancer. We evaluated whether the Cachexia Index (CXI) predicts treatment toxicity and survival in HPV-negative HNSCC. METHODS This study included 353 patients undergoing cura...

G. Savoia, Michael P. Hier, Nader Sadeghi et al. · Head and Neck · 0 citations