Author

Michael R. Tadross

2 papers indexed here

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Open access Aug 2026

Connectomic dopamine-neuron disinhibition accelerates behavioral extinction

Animals must balance persistence with flexibility when outcomes change. Behavioral extinction—the reduction in responding to cues that no longer predict reward—is widely thought to be driven by pauses in dopamine-neuron firing upon omission of expected rewards. However, whether these pauses are necessary remains unknow...

S. Burwell, Rene Carter, Hai-Dun Yan et al. · bioRxiv · 0 citations

Open access Aug 2026

A cholinergic hub in the nucleus accumbens gates opioid-reward learning

Cell-type-specific opioid blockade in accumbal cholinergic interneurons abolishes morphine-reward learning without impairing analgesia and decouples morphine-evoked dopamine elevations from acetylcholine dips, suggesting pro-cholinergic strategies to limit early opioid reward acquisition.

S. Yousefzadeh, Hai-Dun Yan, Seung-Hwa Kwak et al. · Nature · 2 citations