Are components of the histone gene expression machinery functionally repurposed in terminally differentiated cells?
It is shown that in muscle and neural cells that have ceased to replicate their chromatin and permanently exited the cell cycle, HLBs are dismantled and NPAT, FLASH and Lsm11 are detected in the cytoplasm, suggesting that in postmitotic cells, NPAT and U7 snRNP become repurposed for functions unrelated to generating hi...