Michal Šmahel

Macrophages in tumors with downregulated MHC-I expression: emerging therapeutic opportunities and translational challenges

Abstract Tumor-associated macrophages (TAMs) are the dominant component of the tumor microenvironment and exhibit remarkable phenotypic plasticity and heterogeneity that extends beyond the classical M1/M2 polarization, as revealed by single-cell transcriptomics across multiple cancer types. Downregulation of major hist...