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Author

Michel Alchoueiry

2 papers indexed here

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Open access Sep 2026

42 Spatial Mapping of the Sarcomatoid Transition in Chromophobe Renal Cell Carcinoma Reveals a Reprogrammed Tumor-Immune Interactome

Abstract Background Chromophobe Renal Cell Carcinoma (ChRCC), derived from the intercalated cells of the collecting duct, typically follows an indolent clinical course. However, approximately 5–8% of cases undergo sarcomatoid transformation (sChRCC), a high-grade dedifferentiation resulting in a spindle-cell morphology...

Yan Tang, Tie-Gang Han, K. Collins et al. · 0 citations
Open access Jul 2026

mTORC1 activation induces B7-H3-dependent metabolic reprogramming in renal cell carcinoma (RCC)

Renal cell carcinoma (RCC) affects over 435,000 people worldwide each year and remains a significant cause of cancer mortality. Aberrant activation of pathways such as mTORC1 is frequently observed in RCC, yet the mechanisms by which mTORC1 contributes to tumor development remain poorly understood. The lack of suitable...

Keying Li, H. Du, Yi-Fan Wang et al. · 0 citations

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