Author

Michel DuPage

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Sep 2026

Abstract PR009: CD4+ T cells instruct cancer-associated fibroblasts to promote immune control of pancreatic cancer

Cancer-associated fibroblasts (CAFs) are key regulators of tumor progression and therapeutic response in pancreatic ductal adenocarcinoma (PDAC). While CAF-mediated immune modulation has been extensively studied, it remains poorly understood whether adaptive immune cells reciprocally shape CAF heterogeneity and funct...

Jessica Hung, Stephanie L. Silveria, Jenna Vickery et al. · Cancer Research · 0 citations

Open access Jul 2026

Immunotherapeutic control of MHC I-heterogeneous tumors to minimize therapy resistance 2307892

It is demonstrated for the first time in a controlled setting with mixed MHC I+/- tumors that anti-PD-1 therapy selects for outgrowth of MHC I-deficient tumor cells, dependent on CD8 T cells.

Abigail Mende, Sooyun Cho, Chenyu Zhang et al. · Journal of Immunology · 0 citations

Open access Aug 2026

Improved cross-presentation enabled by fusion-dependent mini-proteins that efficiently reach the dendritic cell cytosol

It is shown that substantive improvements in cytosolic antigen delivery provided by the fusion-dependent mini-protein ZF5.3 result in concomitant improvements in MHC-I-mediated antigen presentation and B3Z T-cell activation, which could improve the design of peptide vaccines for immunotherapy.

Teresia Chen, Michel DuPage, Alanna Schepartz · bioRxiv · 0 citations