Open access
Sep 2026
Disrupting peripheral serotonin synthesis drives sex-specific alterations in sociability and cognition, and reshapes the gut-immune-brain axis.
A role for peripheral 5-HT in behavioral regulation is supported and cross-system associations consistent with sex-specific modulation along the gut-immune-brain axis are revealed, while identifying TPH1-dependent signaling as a potential contributor to neuropsychiatric disorders' pathophysiology is identified.
Rogério C. R. Castro, N. Alenina, E. E. Natasha et al.
· Brain, behavior, and immunit... · 0 citations