Author

Michel Sadelain

2 papers indexed here

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Aug 2026

CAR T cell-derived TNF is an early determinant of cytokine release syndrome severity.

Cytokine release syndrome (CRS) is a common and potentially severe toxicity of chimeric antigen receptor (CAR) T cell therapy, characterized by activation of the host myeloid compartment and systemic inflammation. Although downstream effectors such as interleukin-6 (IL-6) and IL-1β are well-characterized, the upstream...

P. Lindenbergh, Theodoros Giavridis, Ophélie Vivier et al. · Science immunology · 2 citations

Open access Aug 2026

Control of breast cancer patient-derived xenografts by CD70-targeted HIT-CAR T cells

It is shown that a subset of breast cancer cell lines and patient-derived xenografts express CD70, albeit to varying levels, and enhanced-sensitivity receptor designs such as HIT receptors to engage a broader range of tumors are highlighted.

P. Lindenbergh, V. Rajasekhar, I. Linkov et al. · Frontiers in Immunology · 0 citations