Author

Michelangelo Campanella

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Open access Aug 2026

Dual inhibition of SGLT 1 and 2 by sotagliflozin alleviates intracellular sodium overload and improves cardiometabolic remodelling in uraemic cardiomyopathy.

AIMS Chronic kidney disease (CKD) is associated with uraemic cardiomyopathy characterised by early metabolic dysfunction. Elevated myocardial intracellular sodium (Naᵢ) has emerged as a driver of cardiometabolic remodelling, however, its role in CKD and therapeutic modulation remains unclear. We investigated whether du...

Megan Young, A. Karlstaedt, Sanushi Dambure et al. · Cardiovascular Research · 0 citations

Review Open access Aug 2026

TSPO: a conserved mitochondrial conduit linking cellular homeostasis to disease

The translocator protein (TSPO) is an evolutionarily conserved 18 kDa protein localised to the outer mitochondrial membrane and increasingly recognised as a multifunctional regulator of cellular homeostasis. Although initially identified as the peripheral benzodiazepine receptor, TSPO has since been implicated in a...

Asif Rasheed, E. Sidlauskaite, Michelangelo Campanella · Cell Death & Disease · 0 citations