A selective small-molecule TRIM28 inhibitor is developed that binds the TRIM28 PHD-bromodomain, phenocopies TRIM28 loss across biochemical and cellular assays, exhibits low micromolar anti-leukemia activity, induces neutrophil differentiation, and synergizes with Menin inhibition.
Shandon M. Amos, Chi-Chao Chen, Yichen Xiang et al.· bioRxiv· 0 citations
It is proposed that the FOXA1-PBX1 complex could represent a higher-order regulatory node integrating chromatin accessibility and ER-driven transcriptional output, and functional enrichment analyses showed strong convergence on coherent biological pathways.
An integrated pan-cancer analysis of UPS protein dysregulation, prognostic associations, and mutation-driven remodeling shows that mRNA poorly predicts UPS protein abundance, that a defined set of E3 ligases is recurrently dysregulated across cancers, and that somatic mutations produce coherent UPS protein-quantitative...
Tania J. González-Robles, M. Khan, Paul Sastourné et al.· Cell Death and Differentiati...· 0 citations
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