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Author

Michelle O'Hara-Wright

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Open access Sep 2026

Culture media alter retinal organoid physiology promoting AAV transduction and retinal ganglion cell survival.

Human iPSC-derived retinal organoids offer a human-relevant platform for inherited retinal disease (IRD) gene therapy, yet robust AAV transduction in vitro remains challenging. Here we show that culture in BrainPhys™ (BP) medium markedly enhances AAV-mediated gene delivery. Brief BP exposure during the transduction win...

Michelle O'Hara-Wright, Benjamin Y. Lim, Melissa M. Mangala et al. · 0 citations

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