Author

Mika J. Välimäki

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Open access Aug 2026

Genotype‐Dependent Effects of Mechanical Stretch and GATA4‐Targeted Compound 3i‐1262 in Cardiomyopathy Patient–Derived hiPSC‐Cardiomyocytes

Genetic hypertrophic and dilated cardiomyopathies (HCM and DCM, respectively) are characterised by structural and functional abnormalities that can lead to heart failure. However, current therapies mainly reduce symptoms. Patient‐derived human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes provide a valua...

S. Pohjavaara, S. Kinnunen, H. Ruskoaho et al. · Basic & Clinical Pharmacolog... · 1 citation

Open access Sep 2026

Patient-Derived hiPSC-Cardiomyocytes and Engineered Heart Tissues Reveal Distinct Functional Phenotypes in Inherited Cardiomyopathies

EHTs generated from HCM hiPSC-derived cardiomyocytes showed a progressive decline in apparent force, whereas DCM EHTs fractured over time, suggesting mutation-associated phenotypes in 3D cardiac tissue models, and highlight the utility of hiPSC-based cardiac models for investigating molecular and functional disease mec...

S. Pohjavaara, Q. Majid, L. Huttunen et al. · bioRxiv · 0 citations