Author

Mikaela Koutrouli

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Open access Sep 2026

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal ageing and its relationship to psychiatr...

Hui Yang, Tereza Clarence, Madeline R. Scott et al. · Nature · 3 citations

Open access Sep 2026

Single-cell atlas of transcriptomic vulnerability across brain disorders

Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2. Here, to gain deeper insights into the aetiology of different brain diseases, we used specimens f...

Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al. · Nature · 5 citations

Open access Jul 2026

Spatialproteomics: an interoperable toolbox for analyzing highly multiplexed fluorescence image data

This work demonstrates an end-to-end analysis from raw images to statistical characterization of how cell type composition and spatial distribution vary across indolent and aggressive lymphomas and presents a Python-based toolbox that supports end-to-end analysis of highly multiplexed imaging data.

Matthias Meyer-Bender, Harald Vöhringer, C. Schniederjohann et al. · Nature Methods · 1 citation