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Mikko Taipale

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Open access Sep 2026

Interplay of NuA4/TIP60 and PRC2 Complex Activities in Fusion Driven Endometrial Stromal Sarcoma

Low-grade endometrial stromal sarcoma (LGESS) exhibits frequent chromosomal translocations that fuse various subunits of the NuA4/TIP60 co-activator complex to subunits of the Polycomb Repressive Complex 2 (PRC2) complex. LGESS fusion proteins, such as the commonly occurring JAZF1-SUZ12, have been shown to upregulate g...

Deepthi Sudarshan, Charles Joly-Beauparlant, Stéphanie Bianco et al. · 0 citations
Open access Jul 2026

The Human Bindome: A Proteome-scale Atlas of Designed Binder Candidates

The Human Bindome is presented, a proteome-scale atlas of high-confidence in silico protein binder candidates that positions the Bindome as a resource of genetically encodable perturbagens for site-specific, modular control of protein function.

Julius Wenckstern, Anna M. Díaz-Rovira, Julia A. Kuhn et al. · 0 citations

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