Miku Maeno

Crystal structure of an activity-enhanced hyperthermophilic quinoprotein aldose sugar dehydrogenase

The crystal structures of R64Q/D350N in both the PQQ-unbound and bound forms were determined to elucidate the molecular mechanism underlying these enhancements and indicate that the increased activity and reduced activity of the R64Q/D350N mutant are likely attributable to the enhanced Ca 2+ uptake into the active site...