Development of Blue-to-Near-Infrared rTCO-Caged Fluorogenic Probes for Click-to-Release Monitoring.
Bioorthogonal click-to-release reactions provide a powerful strategy for chemically controlled activation of functional molecules in biological systems. Here, we report the development of a series of 12 trans-cyclooctene-caged fluorogenic probes, including 11 new compounds, covering the blue-to-near-infrared spectral r...