Open access
Sep 2026
Integrated Genomic and Proteomic Analysis Reveals T‐B Lymphocyte Signatures in the MYCN Driven “Immune Desert” of Specific Neuroblastoma Subtypes
ABSTRACT Aims This study aims to systematically dissect how MYCN amplification shapes the immunosuppressive tumor microenvironment (TME) in high‐risk neuroblastoma, elucidating key mechanisms underlying immune evasion. Methods We performed an integrated multi‐omics analysis of bulk RNA‐seq (n = 721), single‐cell RNA‐se...
Jia-Jian Hu, Wenjuan Kang, Jiatong Hu et al.
· CNS Neuroscience & Therapeut... · 0 citations