SEPT5 confers radioresistance by suppressing GSDME-dependent pyroptosis and antitumor immunity in non-small cell lung cancer.
Non-small cell lung cancer (NSCLC) remains a major cause of cancer mortality worldwide, and radioresistance significantly compromises the efficacy of radiotherapy. However, the precise molecular determinants governing NSCLC radiosensitivity remain incompletely defined. Here, we identify SEPT5 as a key regulator of radi...