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Author

Min Li

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Open access Sep 2026

Gomisin N ameliorates autophagy-neuroinflammation imbalance in Parkinson's disease models via modulating the ATG16L1/NLRP3 axis.

GN is a brain-penetrant preclinical candidate that links ATG16L1-dependent autophagy with α-synuclein clearance and NLRP3 inflammasome suppression in PD models and completely abrogated the neuroprotective and anti-inflammatory effects of GN both in vitro and in vivo.

Cheng-Fu Su, Zhi-Qiang Deng, Ka-Yee Ying et al. · 0 citations
Review Open access Aug 2026

New insights on microglial lysosomal acidification: A therapeutic target of neurodegenerative diseases.

Restoration of microglial lysosomal acidification represents a promising therapeutic strategy for neurodegenerative diseases and a prognostic biomarker for disease progression and therapeutic response.

R. Jaganathan, Srilakshmi Vijayakumar, Yinchi Chen et al. · 0 citations

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