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Author

Min Liang

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Open access Sep 2026

Analysis of clinical features and outcomes in a Chinese cohort with ALK fusion across pan-cancer: a retrospective study

Background ALK fusions are validated oncogenic drivers, yet their molecular heterogeneity and therapeutic implications remain poorly characterized. This study defined the landscape of ALK fusion partners, EML4-ALK variants, and co-mutations and their impact on treatment responses in a large Chinese pan-cancer cohort. M...

Meng Zhang, Yi Feng, Xue Du et al. · 0 citations
Open access Jul 2026

Cisplatin-induced ecDNA enhances tumor malignancy and accelerates chemoresistance acquire in gastric cancer.

This study revealed that cisplatin could promote ecDNA generation, which enhanced malignant phenotypes, including cell proliferation, motility and drug resistance, and was associated with poorer patient prognosis, and targeting ecDNA with inhibitors could reverse these effects.

Huanbo Zhu, Lian Chen, Long-Tao Huangfu et al. · 0 citations

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