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Author

Min-Min Luo

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Oct 2026

A cross-species AAV platform for precise microglial interrogation.

Targeting microglia with adeno-associated viruses (AAVs) remains challenging because of inefficient transduction, off-target expression, and inconsistent payload performance. Here, we develop an integrated, Cre-independent AAV platform that combines a compact 446-bp microglia-specific regulatory element (MSRE), a high-...

Feng-Ting Yu, Rui-Yu Wang, Run Di et al. · 0 citations
Open access Aug 2026

Single-cell spatial transcriptomics reveals rewiring of RPE and Müller glia signaling toward photoreceptors following outer segment disruption in Prph2C213Y mice.

It is indicated that PRPH2-associated retinal dystrophy is a multicellular process in which OS disruption drives coordinated RPE and Müller glial remodeling with potentially protective or pro-degenerative effects, and nominate the RPE Nfib-Fstl1 program, Müller glial AP-1 responses with predicted STAT3 involvement, and...

Haoxin Guo, Linfei Wei, Binghan Chen et al. · 0 citations

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