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Aug 2026

Deciphering the polypharmacology of a traditional Chinese formula for MASLD: Network proximity to identifying Akt-modulating active ingredients.

ETHNOPHARMACOLOGICAL RELEVANCE Network proximity analysis quantifies the functional relationships between drug targets and disease modules, offering a promising approach for deciphering complex herbal formulas. However, the biological implications of the central components identified by this network remain unclear. A...

Zhongyu Zhang, Min Wang, Wen-Kui Yang et al. · 0 citations
Open access Jan 2026

Under Chronic, High‐Dose Administration of Wenjing Decoction, the Activation of the Hepatic Nrf2/HO‐1 Pathway Mediates Increased Bilirubin Levels and Associated Reversible Neurologic Dysfunction in Mice

Long‐term and high‐dose exposure to WJD can induce hyperbilirubinemia in mice by activating the hepatic Nrf2/HO‐1 signaling pathway, as well as causing mild hepatic oxidative damage and neurobehavioral abnormalities.

Wei Du, Min Wang, Xiaoxian Song et al. · 0 citations

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