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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ming-Dian Lei

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Review Sep 2026

The emerging landscape of polymerase θ in tumor pathogenesis and precision treatment.

A comprehensive and updated synthesis of Polθ's structural architecture, regulatory networks, and context-dependent functions across major malignancies, including ovarian, breast, lung, and colorectal cancers, and a critical evaluation of current Polθ inhibitors.

Ming-Dian Lei, Yuxuan Li, Zhi-Peng Xie et al. · 0 citations
Open access Aug 2026

Chronic Early-Life Exposure to Dicyclohexyl Phthalate (DCHP) Impairs Host Defense in Caenorhabditis elegans and Is Associated with Transcriptional Alterations in p38 MAPK and Insulin-like Signaling Pathways

It is suggested that DCHP may impair innate immune function through transcriptional alterations in immune- and stress-response pathways, although direct pathway activation or inhibition was not demonstrated.

Yuxuan Li, Siyuan Luo, Ming-Dian Lei et al. · 0 citations

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