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Author

Ming Guo

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2 papers indexed here

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Open access Sep 2026

Leptin attenuates heat stress-induced mitoxyperilysis in porcine Sertoli cells by suppressing the mtDNA-cGAS-STING axis

It is suggested that leptin may serve as a critical guardian of mitochondrial integrity that protects Sertoli cells from heat stress-induced mitoxyperilysis, highlighting its potential to support future therapeutic strategies for heat stress-related male reproductive dysfunction.

Ming Guo, Jin-Yang Zhang, Shan-Shan Gu et al. · 0 citations
Sep 2026

Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling.

Mammalian spermatogenesis is highly sensitive to temperature fluctuations. Sertoli cells provide essential support for germ cell development and are vulnerable to heat stress-induced cellular damage. Heat stress, known to impair spermatogenesis and induce cellular senescence in various cells, poses a significant threat...

Ming Guo, Ya-Wen Gao, Jin-Yang Zhang et al. · 0 citations

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