Open access
Sep 2026
Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis
ABSTRACT Annulus fibrosus (AF) rupture is a key structural event in intervertebral disc degeneration, but effective repair is hindered by the acidic, hypoxic and oxidative microenvironment of the avascular disc. Single‐cell transcriptomic reanalysis and clinical AF specimens identified ferroptosis‐associated redox imba...
Lu Tan, Yan Zheng, Yue Lan et al.
· Advancement of science · 0 citations