Altered Peripheral and Synovial CD8+ T Cell Signatures Are Associated With Disease Activity in Female Early‐Stage Rheumatoid Arthritis
Rheumatoid arthritis (RA) exhibits significant sexual dimorphism, with females being two to three times more susceptible than males. CD8+ T cells are key effector immune cells driving synovial inflammation, bone erosion, and autoimmune injury within RA joints; nevertheless, their sex‐specific pathogenic characteristics...