Ming-Li Jiang

Reactivation of an inert 15-mer antimicrobial peptide by truncation-directed i, i + 7 lactam cyclization.

The parent 15-mer peptide exhibited no activity against Pseudomonas aeruginosa. Previous studies demonstrated that neither all-hydrocarbon stapling (i, i + 4 octenyl bridge) nor divinylpyrimidine exogenous linker cyclization conferred anti-P. aeruginosa activity upon this sequence. In the present study, this peptide se...