Author

Ming-Liang Ji

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Open access Aug 2026

Targeting pro-senescent PTGS2+ macrophages alleviates chondrocyte senescence and osteoarthritis progression.

Findings link macrophage metabolic remodeling to a pro-senescent secreted pathway and suggest a locally delivered strategy for OA, which reduces NEDD4-dependent ubiquitination and stabilizes THBS1 protein.

Yu-Hao Jiang, Wei-Tuo Zhang, Zhuang Li et al. · Cell Reports · 0 citations