Rhein Attenuates Neointimal Hyperplasia by Inhibiting VSMC Proliferation via MAPK-Mediated Downregulation of CDC45.
BACKGROUND Neointimal hyperplasia (NH) is the primary cause of vascular complications following arterial interventions, driven mainly by abnormal proliferation and phenotypic switching of vascular smooth muscle cells (VSMC). Rhein, a natural anthraquinone compound, possesses anti-inflammatory and anti-proliferative pro...