Open access
Sep 2026
Tandem RNA-binding domain architecture drives PKR activation through an intramolecular interface.
Tandem repeats of RNA-binding domains (RBDs), often linked by intrinsically disordered sequences, are prevalent among RNA-binding proteins (RBPs). The inherent flexibility of these arrangements, however, raises the question of whether such domains can adopt defined configurations critical for function. Here, we reveal...
Chong Han, Chen Li, Yi-Feng Xu et al.
· Proceedings of the National... · 0 citations