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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Ming-Rui Zhao

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Open access Oct 2026

ITGB2 promotes HIF-1α/GLUT1 mediated glucose metabolic reprogramming in renal tubular epithelial cells to aggravate the progression of diabetic kidney disease

Diabetic kidney disease (DKD) is characterized by tubular metabolic remodeling, inflammation, and profibrotic injury. However, whether integrin β2 (ITGB2) links high-glucose (HG) stress to hypoxia-inducible factor-1α (HIF-1α)/glucose transporter 1 (GLUT1)-dependent metabolic reprogramming in renal tubular epithelial ce...

Jun Peng, Qiao-Meng Yuan, Lu Zhou et al. · 0 citations

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