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Ming-Shan Chen

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Sep 2026

Exploring the Mechanism of DEHP Promoting Hepatic Fibrosis Based on Network Toxicology by Triggering Lipophagy-Dependent Hepatic Stellate Cell Activation

Di(2-ethylhexyl)phthalate (DEHP), a common environmental endocrine disruptor and agricultural organic pollutant, has drawn wide concern for its hepatotoxicity. However, the molecular mechanisms underlying DEHP-induced hepatic fibrosis remain unclear. Through network toxicology analysis, lipid metabolism and autophagy...

Hao Zhang, Jia-Jing Cui, Jia-Xin Wang et al. · 0 citations
Aug 2026

MFN2-mediated remodelling of ER-mitochondria communication alleviates ochratoxin A-induced hepatocyte ferroptosis by enhancing mitophagy.

It is indicated that disruption of MFN2-dependent ER-mitochondria communication promotes OTA-induced ferroptosis by impairing mitophagy and identify MFN2 as a potential target for mitigating mycotoxin-associated liver injury.

Zi-Yan Hu, Rui-Qi Liu, Yu-Xuan Ouyang et al. · 0 citations

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