Author

Ming-Shu Hsieh

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Open access Oct 2026

Isoleucine102 and tryptophan104 of the Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) are critical for mouse Fcγ receptor binding and inhibition of neutrophil phagocytosis.

Staphylococcus aureus employs a diverse repertoire of immune evasion proteins to escape host defenses. Formyl peptide receptor-like 1 inhibitory protein (FLIPr) is a secreted staphylococcal factor that targets both chemoattractant receptors and Fc gamma receptors (FcγRs) to suppress leukocyte activation and antibody-de...

Chen-Yi Chiang, Chia-Yu Chi, Yun-Ju Lee et al. · International Journal of Bio... · 0 citations

Open access Aug 2026

Development and fit-for-purpose validation of a qPCR assay for biodistribution assessment of plasmid DNA following electrode-needle device-assisted intramuscular electroporation.

Reliable biodistribution assessment is essential for the nonclinical evaluation of plasmid DNA (pDNA)-based therapeutics. Here, we developed and performed fit-for-purpose validation of a TaqMan-based quantitative PCR (qPCR) assay for the absolute quantification of pDNA following electrode-needle device-assisted intramu...

Wan-Ling Wu, Wan-Chun Huang, Kit-Man Chai et al. · International journal of pha... · 0 citations