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Ming Wang

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Review Open access Jul 2026

Immunological barriers and engineering strategies for CAR-T cell therapy in acute myeloid leukemia

These major barriers to effective CAR-T therapy in AML are discussed and emerging engineering strategies developed to address them are summarized, including approaches to improve targeting precision, reinforce CAR-T cell functional fitness, and remodel the suppressive immune niche.

Ya Wang, Tiantian Yu, Ming Wang et al. · Frontiers in Immunology · 0 citations