Phage-Derived Protein-Guided Nanozymes for the Treatment of MRSA-Infected Acute Otitis Media.
A single-atom nanozyme is reported by coupling ferriporphyrin containing monocarboxyphenyl (mFeP) and cell wall binding domain of endolysin from Staphylococcus aureus phage via a bioorthogonal reaction to achieve targeted catalytic elimination of methicillin-resistant Staphylococcus aureus (MRSA).