Alanyl-tRNA synthetase 1 (AARS1) was recently identified as a lactyltransferase responsible for protein lactylation, a modification associated with epigenetic regulation and metabolic adaptation. Here, we report compound XY353, which covalently binds C184 of AARS1, inducing steric clashes with F175 and triggering struc...
Station-based weather forecasting supports daily life and economic activity, yet accurate forecasts require modeling complex spatial dependencies among stations. Recent clustering-based selective modeling offers a promising alternative to dense inter-station interactions. However, a grouping shared across an observatio...
Rong Li, Hai-Xin Xie, Ming-Yang Wang et al.· 0 citations
GLAIM is a Global-Local Adaptive Inter-variable Dependency Modeling framework for multivariate time series imputation that achieves state-of-the-art performance under random and block missingness, remains robust to missing-rate shifts, and benefits from its complementary global and local components.
Ming-Yang Wang, Rong Li, Xiao Wang et al.· 0 citations
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