Dynamic tensile conditioning of mesenchymal stem cell-laden auxetic scaffolds for enhanced YAP-dependent miR-30 enrichment in extracellular vesicles for pulmonary fibrosis therapy.
Mesenchymal stem cell-derived extracellular vesicles are promising for treating pulmonary fibrosis. However, the generation of extracellular vesicles (EVs) bearing potent, specific therapeutic cargo remains a significant clinical challenge. This study aims to demonstrate how a material-instructive strategy can be utili...