Aug 2026
hnRNPK condensates facilitate enhancer–promoter looping and RNA polymerase II recruitment
Rong Ye, Hai-Lian Zhao, Juan Chen et al.
· Nature Genetics · 0 citations
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Aug 2026
IRF8 Transcriptionally Drives NAIP to Promote NLRP3/NLRC4 Inflammasome-Mediated Renal Tubular Pyroptosis in Diabetic Kidney Disease.
OBJECTIVE Renal tubular pyroptosis is a key driver of inflammation and fibrosis in diabetic kidney disease (DKD), yet the contribution of the NAIP-NLRC4 inflammasome arm and its upstream transcriptional control have remained undefined. This study investigated whether NAIP causally promotes tubular pyroptosis in DKD and...
Xiaorong Zou, Rui Su, Xue-Yan Liang et al.
· Experimental Cell Research · 0 citations