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Ming-Zhao Zhu

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Open access Sep 2026

Epigenetic training licenses naïve CD8+ T cell metabolic fitness and function

Naïve T cells maintain quiescence yet must respond rapidly to antigens, but how they prime this capacity is unclear. We identify histone variant H2A.Z as a key regulator of an epigenetic training program that licenses quiescent naïve CD8+ T cells for future activation. H2A.Z deficiency disrupts naïve T cell homeostasis...

Meng-Jie Lv, Ji-Yu Ding, Hai-Zhen Long et al. · 0 citations
Open access Aug 2026

H3.3 chaperone Hira primes the effector program and function of regulatory T cells

It is shown that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program, revealing a previously unreported epigenetic mechanism critical for Treg effector differentiation and function.

Xiang-Xiang Cao, Meng-Jie Lv, Zhi-Han Lv et al. · 0 citations

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