Author

Ming-Zhe Xu

2 papers indexed here

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Open access Aug 2026

Resolving conformational polymorphism in disulfide-rich peptide drugs

Disulfide-rich peptide therapeutics often exhibit compact cystine knot-like architectures that endow them with high conformational rigidity, proteolytic stability, and target specificity. Yet their intrinsic polymorphism and structural heterogeneity are difficult to resolve with conventional analytical methods, which l...

Shao-Zhou Zhu, Yi-Feng Ge, Haiwei Huang et al. · Frontiers in Chemistry · 0 citations

Open access Sep 2026

Prediction of Ocular Toxicity of Prostaglandin F2α Analogs Based on Local Computational Models: Superiority over Global Models and Experimental Validation

Results show how a localized modeling approach is better able to capture structure–toxicity correlations among chemically similar compounds and highlight the critical need for rigorous impurity management in latanoprost products, particularly regarding 15(S)-latanoprost.

Xin-Yi Lu, Li Ren, Chen Wang et al. · Molecules · 0 citations