Identification of Pre-Diagnostic Protein Biomarkers for Liver Cirrhosis Based on Prospective Analysis of a Large-Scale Plasma Proteomics in the UK Biobank.
PURPOSE Liver fibrosis and cirrhosis represent critical stages in the progression of chronic liver disease, yet their key molecular features remain incompletely understood. EXPERIMENTAL DESIGN We performed large-scale Olink-based proteomic profiling in over 40,000 participants from the UK Biobank with a median follow...