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Author

Minoru Kobayashi

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Open access Aug 2026

The lariat RNA debranching enzyme DBR1 enhances HIF-1 signaling and chemoresistance at the expense of lariat RNA processing.

Severely hypoxic microenvironments that induce cell-cycle arrest and chemoresistance are frequently found within solid tumors. Since hypoxia-inducible factor 1 (HIF-1) serves as a central transcription factor for cellular adaptation to oxygen deprivation, identification of novel regulators of HIF-1 activity may provide...

Phuong Thi Lien Nguyen, Minoru Kobayashi, S. Koyasu et al. · 0 citations
Open access Sep 2026

IDH3-dependent mitochondrial function in stromal fibroblasts suppresses malignant tumor growth

Findings identify IDH3α-dependent mitochondrial function in fibroblasts as a critical determinant of tumor progression and suggest that stromal mitochondrial metabolism represents an important axis for modulating tumor behavior.

L. R. Koseki, Minoru Kobayashi, Mai Ito et al. · 0 citations

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