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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Minseok Seo

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Open access Sep 2026

Betaine-driven Keap1 methylation promotes p62-mediated autophagy and Nrf2 stabilization to alleviate glutathione-dependent redox dyshomeostasis in liver injury

Evidence is provided that betaine (trimethylglycine; BET) can regulate the Keap1-Nrf2 axis through modulation of Keap1 and that Keap1 cysteine methylation may represent a regulatory node linking betaine to p62-mediated autophagy, Nrf2 stabilization, and GSH homeostasis.

Moon-Han Chang, Chae Hwan Lee, Yeongrae Cho et al. · 0 citations

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