Open access
Jul 2026
Macrophage NPM1 drives anti-tumor immunity via the STAT3-CCRL2 axis
Overexpression of NPM1 in mice suppressed tumor growth, reduced M2 TAMs polarization, and enhanced CD8+ T cell-mediated anti-tumor immunity, revealing that NPM1 protects against tumor progression by regulating TAMs polarization and T cell function via the STAT3-CCRL2 axis.
Lei Hong, Yue Yang, Yuwen Han et al.
· Frontiers in Immunology · 0 citations