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Minxuan Sun

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Open access Jul 2026

Macrophage NPM1 drives anti-tumor immunity via the STAT3-CCRL2 axis

Overexpression of NPM1 in mice suppressed tumor growth, reduced M2 TAMs polarization, and enhanced CD8+ T cell-mediated anti-tumor immunity, revealing that NPM1 protects against tumor progression by regulating TAMs polarization and T cell function via the STAT3-CCRL2 axis.

Lei Hong, Yue Yang, Yuwen Han et al. · 0 citations

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