Author

Mireia N. A. Bernabé Kleijn

2 papers indexed here

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Open access Sep 2026

IL-21R blockade reduces inflammation and atherosclerosis in LDL receptor deficient mice.

BACKGROUND Interleukin-21 (IL-21) is a pro-inflammatory cytokine involved in the regulation of both innate and adaptive immune responses and has been associated with atherosclerotic cardiovascular disease (ASCVD). However, the exact role of IL-21/IL-21R signaling in atherosclerosis and the therapeutic potential of targ...

R. Snijckers, V. Smit, R. Postel et al. · Atherosclerosis · 0 citations

Open access Sep 2026

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

ABSTRACT Aging is a major risk factor for atherosclerosis and is accompanied by profound changes in the immune system, including effector T cell expansion, senescent cell accumulation, and increased pro‐inflammatory signaling. Rapamycin, a promising rejuvenation therapeutic that inhibits mTORC1 and modulates immune agi...

J. de Mol, D. D. de Korte, M. Depuydt et al. · Aging Cell · 0 citations